The recent global pandemic has highlighted the impact of nucleic acid-based modalities.
Messenger RNA (mRNA) and double stranded DNA plasmids are being used in emerging
gene and cell therapies. Large sized nucleic acid moieties remain challenging to analyze
using traditional LC-MS techniques due to structural heterogeneity, ionization and
detection limitations. IonDXTM has developed a bench-top atmospheric pressure ion
mobility spectrometer, IMgeniusTM to address such challenges. This patented technology
was used to profile native mRNA and DNA constructs ranging in sizes from 320kD to