Rapid Screening of Megadalton mRNA and dsDNA using IMgenius


The recent global pandemic has highlighted the impact of nucleic acid-based modalities.

Messenger RNA (mRNA) and double stranded DNA plasmids are being used in emerging

gene and cell therapies. Large sized nucleic acid moieties remain challenging to analyze

using traditional LC-MS techniques due to structural heterogeneity, ionization and

detection limitations. IonDXTM has developed a bench-top atmospheric pressure ion

mobility spectrometer, IMgeniusTM to address such challenges. This patented technology

was used to profile native mRNA and DNA constructs ranging in sizes from 320kD to


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